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Supplements

Vitamins, minerals and other supplemental compounds.
Short explanations show the finding and its limits. Paper records link you to the source.

2,701 papers in this topic256 short explanations
Supplements2 min read

PCOS supplement review found laboratory changes, with several results uncertain

Trials in women with polycystic ovary syndrome reported different laboratory results for different supplements. Several measurements did not differ significantly from placebo, and symptom benefits remain unestablished by these results.

Systematic review and network meta-analysis of 79 randomized controlled trials.2025
30-second takeaway

In women with polycystic ovary syndrome, the review reported changes in cholesterol, insulin-resistance and other laboratory measurements with different supplements. Several hormone and inflammation-related outcomes showed no statistically clear differences from placebo. These findings describe specific laboratory endpoints; they do not establish broad symptom relief or identify a supplement that is best for every outcome.

Keep in mind: The abstract gives rankings without effect sizes, confidence intervals or treatment durations. It does not report corresponding symptom outcomes, limiting assessment of the practical importance of the laboratory changes.

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Abstract-based explanation

Supplements2 min read

Cinnamon supplementation changed cardiovascular risk measurements in a pooled review

Studies in adults reported lower blood pressure, glucose and several blood fats with cinnamon supplementation. The abstract does not establish fewer cardiovascular events or explain the comparison treatments.

Systematic review and meta-analysis of randomized controlled trials; 49 studies included.2025
30-second takeaway

In studies of adults, cinnamon supplementation lowered several measured cardiovascular risk factors in the pooled analysis, including blood pressure, fasting glucose and cholesterol measurements. The abstract does not identify the comparison treatments or report cardiovascular events. Changes in these measurements therefore cannot establish that cinnamon prevents heart disease or provide a basis for choosing a dose.

Keep in mind: The abstract omits comparator details, treatment durations, doses and participant characteristics. It reports standardized effects without changes in ordinary clinical units, limiting assessment of how noticeable the differences were.

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Abstract-based explanation

Supplements2 min read

Curcumin trial reports changes in inflammation and liver measurements

In patients with diabetes and metabolic fatty liver disease, curcumin lowered an inflammation marker and liver measurements compared with placebo. The abstract gives no effect sizes.

Randomized trial with double blinding and a placebo control.2025
30-second takeaway

Curcumin lowered tumor necrosis factor, the primary outcome, compared with placebo at every follow-up. The abstract also reports lower liver fat and stiffness, which were secondary outcomes. These findings concern inflammation and liver measurements; they do not establish fewer clinical complications or reveal how large the differences were.

Keep in mind: This abstract-based account lacks effect sizes and confidence intervals for the main results. Adverse-event results are also absent, limiting assessment of benefit magnitude and tolerability.

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Abstract-based explanation

Supplements2 min read

A trial-derived score explores differences in supplement benefit

Among participants without cardiovascular disease, a new score separated groups with different coronary heart disease results for omega-3 supplements versus placebo. The score needs testing in another trial.

Prediction-score analysis using machine learning, a method for finding patterns, within a randomized trial.2025
30-second takeaway

Expected supplement benefit appeared to vary among participants without cardiovascular disease. Above the score threshold, coronary heart disease risk was lower with omega-3 than with placebo; below it, risks were numerically similar. The score remains exploratory and needs testing in another randomized trial before its predictions can be considered established.

Keep in mind: Transfer to survey data does not replace testing in a new randomized trial. The abstract reports no confidence intervals for the score-defined risk comparisons.

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Abstract-based explanation

Supplements2 min read

Adding collagen improved reported outcomes during knee arthritis flare-ups

Patients with knee osteoarthritis receiving collagen alongside a combination treatment had greater pain-score improvements than those receiving the same mixture without collagen. The abstract leaves important treatment and reporting details unspecified.

Prospective randomized comparison conducted at a single center.2025
30-second takeaway

In this trial, adding collagen to the combination was associated with greater reductions in reported knee pain, improved functional measurements and less use of anti-inflammatory medication than the collagen-free combination. The findings concern this specific mixture during osteoarthritis flare-ups. They do not establish what collagen alone would do or whether improvements persisted beyond follow-up.

Keep in mind: The abstract does not report ingredient doses, blinding or adverse events. It also does not clearly specify when the headline pain reductions were measured, limiting interpretation of their timing and practical significance.

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Abstract-based explanation

Supplements2 min read

An added herbal medicine improved reported hip-replacement recovery scores

Hip-replacement patients receiving Xianlinggubao alongside postoperative care, vitamin D and alendronate had better pain and hip-function scores. The abstract gives no effect sizes or demonstrated prosthesis-survival result.

Randomized comparison of postoperative treatment with and without Xianlinggubao.2025
30-second takeaway

Patients receiving the added herbal medicine had lower pain scores and higher hip-function scores than those receiving postoperative care, vitamin D and alendronate without it. Bone-related laboratory measurements also differed. The abstract does not quantify the clinical improvements or report a prosthesis-survival outcome, so it cannot show how much recovery improved or whether implants lasted longer.

Keep in mind: The abstract omits effect sizes, confidence intervals, treatment doses and adverse-event results. Although prosthetic survival was part of the stated question, no direct survival or implant-failure result is reported.

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Abstract-based explanation

Supplements2 min read

Pregnancy vitamin D showed no clear maternal bone-density advantage

Mothers assigned vitamin D during pregnancy had no statistically clear bone-density advantage over placebo after delivery or years later, despite higher vitamin D levels in late pregnancy.

Post hoc follow-up analysis of a randomized placebo-controlled trial.2025
30-second takeaway

Vitamin D supplementation increased mothers' blood vitamin D levels in late pregnancy, but did not produce statistically clear differences in bone mineral density compared with placebo after delivery or several years later. Bone mineral density measures mineral content in bone. These results concern mothers' bone density, and do not establish effects on fractures or other health outcomes.

Keep in mind: This was a post hoc analysis. The abstract gives no confidence intervals for bone-density differences and reports bone density rather than fractures, leaving small effects and clinical outcomes uncertain.

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Abstract-based explanation

Supplements2 min read

Magnesium gel showed no recovery advantage after unfamiliar exercise

In healthy, active participants, magnesium gel showed no detected advantage over placebo after downhill running. The trial assessed soreness, knee strength and blood markers.

Randomized, double-blind trial with separate treatment groups.2025
30-second takeaway

After an unfamiliar downhill run, participants given magnesium gel had no detected advantage over placebo in soreness, knee strength or the measured blood markers. Soreness increased after exercise in both groups. This trial therefore did not demonstrate better recovery with the tested gel, although it does not establish equivalence between treatments.

Keep in mind: The abstract reports no confidence intervals for treatment differences, preventing assessment of whether a meaningful benefit could be excluded. This abstract-based summary applies to the tested product and application schedule.

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Abstract-based explanation

Supplements2 min read

Supplement blend showed some muscle-size differences, but no strength advantage

In recreationally active men doing resistance training, a supplement blend improved selected muscle-size measures versus placebo. No differences from creatine alone, or between groups for strength and endurance, were detected.

Comparative supplementation study conducted alongside resistance training.2025
30-second takeaway

During resistance training, the blend group had greater combined quadriceps area than placebo, but no detected difference from creatine alone. Strength and endurance outcomes did not differ between groups. The results therefore suggest selected muscle-size differences without demonstrating that the blend offers an advantage over creatine or improves training performance.

Keep in mind: The abstract gives no effect sizes or confidence intervals for group differences and does not describe allocation methods. The findings concern recreationally active men over a short training period.

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Abstract-based explanation

Supplements2 min read

Curcumin-piperine changed blood tests in intensive-care sepsis patients

Compared with placebo, curcumin-piperine changed several laboratory measurements in critically ill patients with sepsis. The abstract does not establish whether those changes translated into improved survival or recovery.

Randomized, placebo-controlled trial described as double-blind.2025
30-second takeaway

In critically ill patients with sepsis, curcumin-piperine produced statistically significant changes in several blood measurements compared with placebo. These included a lower inflammation marker, but the clinical meaning of the overall pattern remains uncertain. Deaths occurred in both groups, and the abstract provides no statistical assessment showing whether survival differed.

Keep in mind: The abstract reports statistical significance without the sizes of laboratory changes. It does not provide a mortality comparison with uncertainty estimates, so the death counts alone cannot establish a survival effect.

Study details & source ↗

Abstract-based explanation

Supplements2 min read

A supplement study measured short-term laboratory changes after COVID-19

A plant supplement and vitamin C showed changes in laboratory markers in people recovering from infection. The abstract does not establish faster recovery or symptom improvement.

Randomized, double-blind study.2025
30-second takeaway

The abstract reports changes in several measures of reactive oxygen molecules after the plant supplement, and a narrower set after vitamin C. These were immediate laboratory findings in people recovering from infection. Without reported symptom or recovery results, they do not establish that either product helped participants feel better or recover faster.

Keep in mind: This abstract-based explanation cannot assess clinical benefits from the laboratory results. Direct between-group estimates for the circulating nitric oxide marker are absent, so different significance results within groups cannot establish superiority.

Study details & source ↗

Abstract-based explanation

Supplements2 min read

Both vitamin D doses corrected deficiency in most children studied

Among children with overweight or obesity and vitamin D deficiency, both doses usually reached the blood threshold. Neither showed significant metabolic changes.

Open-label randomized trial, with treatment allocation known.2025
30-second takeaway

Most children in both dose groups reached the study's vitamin D sufficiency threshold. The higher dose raised blood vitamin D faster, but neither group showed significant metabolic changes. Some children developed mild, symptom-free high blood calcium that resolved spontaneously. These short-term findings apply to children with both excess weight and established deficiency.

Keep in mind: The trial was open-label, and not every enrolled child completed it. The short follow-up cannot establish ongoing safety or effectiveness beyond the study period.

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Abstract-based explanation

Supplements2 min read

Omega-3 supplements and vision: results vary by age and condition

A review found mixed vision-related results across life stages. Findings were generally more favorable in school-age children and some dry eye studies, but a consistent benefit remains unestablished.

Systematic review of 87 articles drawn from randomized, controlled clinical studies.2025
30-second takeaway

Across controlled trials in people at different life stages, omega-3 supplements produced inconsistent vision-related results. Pregnant women, infants and older adults had conflicting findings, while preschool and school-age studies were mostly positive. Adult results depended on the condition studied, with dry eye studies often favorable. This does not establish a consistent benefit for everyone.

Keep in mind: The abstract does not provide trial-level outcomes, effect estimates, follow-up lengths or specific control treatments. It also leaves unresolved the difference between mixed infant findings and its more favorable conclusion.

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Abstract-based explanation

Supplements2 min read

Probiotic trial reports vaginal microbial changes in women with HPV

A placebo-controlled trial reported changes in vaginal bacteria and fungi after probiotic use. Questionnaire findings were also favorable, but the abstract does not report whether HPV infection cleared.

Double-blind, randomized, placebo-controlled study.2025
30-second takeaway

In women positive for HPV, the tested probiotic was studied against placebo over 12 weeks. The probiotic group showed changes in vaginal microbial communities, including more Lactobacillus and less Streptococcus and Candida. Questionnaires also linked probiotic use with better reported vaginal and mental health. These findings do not establish that the probiotic cleared HPV infection.

Keep in mind: The abstract omits participant count, numerical questionnaire effects and the comparison underlying each microbial change. It reports favorable microbial diversity without explaining what that meant quantitatively or how it related to clinical outcomes.

Study details & source ↗

Abstract-based explanation

Supplements2 min read

Omega-3 trial reports lower depression scores in men with bipolar disorder

Men with bipolar disorder receiving omega-3 had lower depression rating scores than those receiving placebo after a short trial; longer-term outcomes were not described.

Randomized, double-blind, placebo-controlled clinical trial.2025
30-second takeaway

In this trial, men with bipolar disorder receiving omega-3 supplements had lower depression scores than the placebo group at the end of treatment. A blood protein measurement also increased. The symptom scores are the clinically relevant finding here, but the abstract does not establish remission, lasting improvement, or applicability beyond the studied men.

Keep in mind: The abstract does not describe other treatments, adverse effects, or longer-term outcomes. It also does not explain what the reported plus-or-minus values represent.

Study details & source ↗

Abstract-based explanation

Supplements2 min read

Small artery disease pilot reports cognitive changes after nicotinamide riboside

An open-label pilot in older adults with peripheral artery disease reported improved cognitive performance after nicotinamide riboside supplementation. No control group is described, so the findings cannot establish a supplement effect.

Open-label pilot clinical trial, accompanied by experiments using patient blood serum and cultured cells.2025
30-second takeaway

This small pilot reported improved cognitive performance and a brain blood-vessel response after supplementation, while peripheral blood-vessel function showed only a positive trend. With no control group described and no numerical cognitive effects provided, the abstract cannot attribute these changes to nicotinamide riboside or establish lasting benefits for people with peripheral artery disease.

Keep in mind: This abstract-based account covers a short, open-label study with few participants. It provides no control comparison or numerical cognitive results, and cannot establish prevention of cognitive decline or broader health benefits.

Study details & source ↗

Abstract-based explanation

SupplementsPaper record

Efficacy of vitamin D supplementation in patients diagnosed with depression: a dose-response meta-analysis of randomized controlled trials.

Systematic review · Front Nutr · 2026. Source record refreshed; an explanation has not been reviewed.

Systematic review2026
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SupplementsPaper record

Effect of dietary nutrient supplementation on birth outcomes in pregnant women with gestational diabetes mellitus: A network metaanalysis.

Meta-analysis · Nutrition · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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SupplementsPaper record

Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.

Meta-analysis · Front Immunol · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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SupplementsPaper record

Preventing Hand-Foot Syndrome in Patients With Cancer: A Systematic Review and Network Meta-Analysis.

Meta-analysis · JAMA Dermatol · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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SupplementsPaper record

Anti-inflammatory effects and safety of omega-3 fatty acids in haemodialysis: A systematic review and meta-analysis.

Meta-analysis · Clin Nutr ESPEN · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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SupplementsPaper record

Effect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults-Results from the Randomized Controlled D-Health Trial.

Randomized controlled trial · Nutrients · 2026. Source record refreshed; an explanation has not been reviewed.

Randomized controlled trial2026
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SupplementsPaper record

Marine n-3 fatty acid treatment for carotid plaques in patients with type 2 diabetes.

Randomized controlled trial · Cardiovasc Diabetol · 2026. Source record refreshed; an explanation has not been reviewed.

Randomized controlled trial2026
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SupplementsPaper record

Preoperative Testosterone Replacement Therapy Is Associated With Increased Complication Risk After Total Hip Arthroplasty: A Propensity-Matched Analysis of Real-World Data.

Study design not specified in the source record · J Arthroplasty · 2026. Source record refreshed; an explanation has not been reviewed.

Study design not specified in the source record2026
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