Supplement blend showed some muscle-size differences, but no strength advantage
In recreationally active men doing resistance training, a supplement blend improved selected muscle-size measures versus placebo. No differences from creatine alone, or between groups for strength and endurance, were detected.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
During resistance training, the blend group had greater combined quadriceps area than placebo, but no detected difference from creatine alone. Strength and endurance outcomes did not differ between groups. The results therefore suggest selected muscle-size differences without demonstrating that the blend offers an advantage over creatine or improves training performance.
The abstract gives no effect sizes or confidence intervals for group differences and does not describe allocation methods. The findings concern recreationally active men over a short training period.
What researchers found
Muscle size after 8 weeks
Adjusted post-training summed cross-sectional area favored the blend over placebo; no difference from creatine alone was detected. The magnitude was not reported.
What muscle size meant
Cross-sectional area describes muscle size in a slice. Researchers examined individual quadriceps muscles and their combined area. The blend's differences from placebo concerned the combined measure and a particular muscle, rather than every measured muscle.
A separate threshold analysis
Researchers also compared how many participants exceeded a threshold for an important change. Creatine alone exceeded placebo on this analysis of combined muscle area. That finding does not establish a difference in average muscle size between those groups.
The original publication
Effects of a Blend of Trisodium Citrate, Creatine Monohydrate, Leucine, and Blueberry Extract on Training-Induced Changes in Leg Extension Strength, Endurance, and Muscle Size.
Roberts TD, Arnett JE, Ortega DG et al.
J Diet Suppl · 2025
- PubMed ID
- 40537085
- Record checked
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