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Healthy aging

Aging, lifespan and changes in health over time.
Short explanations show the finding and its limits. Paper records link you to the source.

707 papers in this topic53 short explanations

Blood klotho showed no clear link to falls or muscle measures

Researchers detected no associations between blood klotho and falls, grip strength or bone density in healthy older adults. Higher concentrations were associated with smaller waists in women only.

Exploratory analysis of associations within the STOP IT clinical trial.2025
30-second takeaway

This analysis did not find that blood klotho, studied as a possible marker of aging, tracked falls or the measured muscle and bone outcomes in healthy older adults. Its association with waist size appeared only in women. That isolated association does not establish a cause or demonstrate usefulness for assessing muscle and bone health.

Keep in mind: This abstract-based summary concerns an exploratory analysis in healthy older adults. Estimates and confidence intervals for the undetected associations are absent, so their precision cannot be assessed.

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Abstract-based explanation

A vertebrate review found lifespan extension with dietary restriction and rapamycin

Metformin lacked statistically supported lifespan extension in this analysis. Differences among studies and publication bias complicate the findings.

Meta-analysis of published lifespan findings across vertebrate species.2025
30-second takeaway

Across vertebrate studies, dietary restriction and rapamycin showed statistically supported lifespan extension, while metformin did not. The authors described rapamycin and dietary restriction findings as comparable. However, substantial differences among studies, publication bias and sensitivity to lifespan reporting limit that interpretation. This abstract does not establish a lifespan benefit for people.

Keep in mind: The abstract provides no numerical lifespan gains or precise between-treatment comparison. It reports substantial study variation and publication bias, so the apparent similarity cannot establish equivalence.

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Abstract-based explanation

CD38 research is expanding; this abstract gives no treatment-benefit estimates

A publication analysis maps growing interest in CD38, a protein involved in cellular metabolism. Its abstract discusses possible clinical uses without reporting measured treatment benefits.

Bibliometric analysis of publication patterns, followed by a synthesis of research insights.2025
30-second takeaway

This study maps increasing publication activity around CD38, with the United States and China identified as leading research hubs. Its synthesis discusses the protein's involvement in aging and related diseases. The abstract describes potential clinical applications but provides no measured treatment benefits, so it cannot establish whether targeting this protein improves patients' health.

Keep in mind: The abstract omits the literature's size, search period and evidence certainty. This abstract-based explanation cannot assess the supporting studies or determine how much patient-outcome evidence lies behind the proposed clinical applications.

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Abstract-based explanation

A review maps how airway tissues change with aging

This review describes molecular changes across the windpipe and branching airways, including altered mucus clearance and tissue stiffness. It does not report a treatment comparison or a measured clinical benefit.

Systematic review of literature about molecular changes in aging airway tissues.2025
30-second takeaway

The review brings together research on how aging affects the lining, supporting tissues, cartilage, and muscle of the airways. It describes changes connected with poorer clearance of mucus, inflammation, and altered tissue structure. This is a summary of biological processes, rather than evidence that a particular intervention prevents breathing problems in older people.

Keep in mind: The abstract does not identify the included studies, their populations, or how their quality was assessed. It provides no numerical estimates showing the strength of links between tissue changes and respiratory outcomes.

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Abstract-based explanation

Antioxidant review reports changes in cell ageing markers, with clinical meaning unresolved

A review compared natural and synthetic antioxidants using markers of cell ageing. It reports favorable findings, but does not identify the study populations or establish benefits for people.

Systematic review of 33 studies.2025
30-second takeaway

The review reports that both natural and synthetic antioxidants reduced markers associated with cell ageing. Natural options often performed similarly to, or better than, synthetic options, and some combinations had favorable results. However, the abstract does not identify whether these findings came from cells, animals or people. Changes in markers therefore cannot establish healthier ageing or longer life.

Keep in mind: The abstract does not identify study models or participant populations, specific marker measurements, doses, follow-up lengths or numerical comparisons. Its broad summaries cannot establish the size or clinical relevance of the reported changes.

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Abstract-based explanation

Healthy agingPaper record

Low Testosterone Levels and Grade Group Progression Among Localized Prostate Cancer Patients on Active Surveillance: A Retrospective Cohort Study.

Cohort study (title) · J Urol · 2026. Source record refreshed; an explanation has not been reviewed.

Cohort study (title)2026
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Healthy agingPaper record

Medication Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).

Randomized controlled trial · Diabetes Care · 2026. Source record refreshed; an explanation has not been reviewed.

Randomized controlled trial2026
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Healthy agingPaper record

Divergent Trends in Prostate-specific Antigen Screening Prior to Testosterone Therapy in Younger vs Older Men Amidst Shifting Guidelines.

Study design not specified in the source record · Urology · 2026. Source record refreshed; an explanation has not been reviewed.

Study design not specified in the source record2026
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Healthy agingPaper record

Molecular mechanisms and risk factors in rheumatoid arthritis: a comprehensive review.

Systematic review · Inflammopharmacology · 2026. Source record refreshed; an explanation has not been reviewed.

Systematic review2026
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Healthy agingPaper record

Androgen Receptor Pathway Inhibitor Monotherapy in Prostate Cancer: Safety, Oncologic Outcomes, and Quality of Life-A Systematic Review and Meta-analysis.

Meta-analysis · Eur Urol Focus · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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Healthy agingPaper record

Endoscopic enucleation vs. robot-assisted simple prostatectomy for large prostates: a systematic review and meta-analysis of patients' perspectives.

Meta-analysis · Prostate Cancer Prostatic Dis · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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Healthy agingPaper record

Habitual natto intake elevates serum MK-7 levels, enhances osteocalcin carboxylation, and supports bone density: a meta-analysis of Japanese evidence.

Systematic review · Front Nutr · 2025. Source record refreshed; an explanation has not been reviewed.

Systematic review2025
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Healthy agingPaper record

Evidence-Based Pathways to Healthy Aging: A Systematic Review and Meta-analysis of Lifestyle Interventions for Longevity and Well-Being.

Meta-analysis · Invest Educ Enferm · 2025. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2025
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Healthy agingPaper record

Biological age measured by DNA methylation clocks and frailty: a systematic review and meta-analysis.

Meta-analysis · Lancet Healthy Longev · 2025. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2025
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Healthy agingPaper record

Can table tennis protect the aging brain? A systematic review and meta-analysis in neurodegenerative diseases.

This publication is retracted. Read the source notice before using its findings.

Meta-analysis2025
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The current PubMed record links a retraction. This catalog does not present the publication as reliable practical guidance.

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Retracted paper

Healthy agingPaper record

Study of the predictive value of testosterone in androgen deprivation therapy for metastatic hormone-sensitive prostate cancer-the dual clinical research center for western and eastern China.

Study design not specified in the source record · Front Endocrinol (Lausanne) · 2025. Source record refreshed; an explanation has not been reviewed.

Study design not specified in the source record2025
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Healthy agingPaper record

Simple hysterectomy with pelvic lymphadenectomy versus radical hysterectomy with pelvic lymphadenectomy for women with stage IA2-IB1 cervical cancer.

Meta-analysis · Cochrane Database Syst Rev · 2025. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2025
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Healthy agingPaper record

Effect of repurposed simvastatin on disability progression in secondary progressive multiple sclerosis (MS-STAT2): a phase 3, randomised, double-blind, placebo-controlled trial.

Randomized controlled trial · Lancet · 2025. Source record refreshed; an explanation has not been reviewed.

Randomized controlled trial2025
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Healthy agingPaper record

The molecular mechanisms of mitochondrial dynamics and mitophagy and their complex association with cancer drug resistance.

Systematic review · J Transl Med · 2025. Source record refreshed; an explanation has not been reviewed.

Systematic review2025
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Healthy agingPaper record

Supramarginal Resection of Metastatic Brain Tumors: A Meta-Analysis Study.

Meta-analysis · Medicina (Kaunas) · 2025. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2025
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Healthy agingPaper record

The impact of hypoprolactinemia on cardiometabolic effects of metformin in young women: a pilot prospective cohort study.

Cohort study (title) · J Endocrinol Invest · 2025. Source record refreshed; an explanation has not been reviewed.

Cohort study (title)2025
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Healthy agingPaper record

Aging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential.

Systematic review · J Cosmet Dermatol · 2025. Source record refreshed; an explanation has not been reviewed.

Systematic review2025
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Healthy agingPaper record

The role of photobiomodulation in modulating neural activity and brain function: A systematic bibliometric analysis.

Systematic review · Photodiagnosis Photodyn Ther · 2025. Source record refreshed; an explanation has not been reviewed.

Systematic review2025
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Healthy agingPaper record

The Role of Estrogen in Mitochondrial Disease.

Systematic review · Cell Mol Neurobiol · 2025. Source record refreshed; an explanation has not been reviewed.

Systematic review2025
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