Blood klotho showed no clear link to falls or muscle measures
Researchers detected no associations between blood klotho and falls, grip strength or bone density in healthy older adults. Higher concentrations were associated with smaller waists in women only.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
This analysis did not find that blood klotho, studied as a possible marker of aging, tracked falls or the measured muscle and bone outcomes in healthy older adults. Its association with waist size appeared only in women. That isolated association does not establish a cause or demonstrate usefulness for assessing muscle and bone health.
This abstract-based summary concerns an exploratory analysis in healthy older adults. Estimates and confidence intervals for the undetected associations are absent, so their precision cannot be assessed.
What a marker would need to show
A biomarker is a measurable biological indicator. Researchers asked whether blood klotho concentrations tracked falls, body composition, strength and bone density. The findings did not support its usefulness for assessing these aspects of aging.
The waist finding has boundaries
Higher klotho concentrations were associated with smaller waist circumference in women after adjustment for several measured factors. The analysis did not detect this association in men, and the finding does not establish better muscle or bone health.
The original publication
Serum klotho is inversely associated with girth in older women but is not associated with falls or musculoskeletal measures in either sex.
Dawson-Hughes B, Konieczynski EM, Ceglia L
J Nutr Health Aging · 2025
- PubMed ID
- 40592050
- Record checked
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