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Gut health

Digestion, the microbiome and gut–brain connections.
Short explanations show the finding and its limits. Paper records link you to the source.

1,089 papers in this topic150 short explanations
Gut health2 min read

COPD supplement trial found no clear changes in gut microbes

In people with chronic obstructive pulmonary disease (COPD), this small exploratory analysis did not demonstrate supplement effects on gut microbes or body-wide inflammation after three months.

Exploratory analysis within a randomized, double-blind, placebo-controlled trial, plus a cross-sectional baseline comparison.2025
30-second takeaway

This preliminary analysis found gut microbial differences between people with COPD and healthy participants. Compared with placebo, the supplement did not demonstrate changes in gut microbes or body-wide inflammation over three months. The small exploratory analysis leaves uncertainty about undetected effects and does not demonstrate a clinical benefit.

Keep in mind: The abstract provides no intervention effect estimates or confidence intervals. Its small, exploratory treatment groups limit what can be concluded about effects that may have gone undetected.

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Abstract-based explanation

Gut health2 min read

Biofeedback review finds mixed results for functional gut symptoms

In studies of adults and children with functional gastrointestinal disorders, heart rate variability biofeedback produced mixed symptom results. Differences in patient groups and missing comparison details limit conclusions about who might benefit.

Scoping review of 4 interventional studies identified through a systematic database search.2025
30-second takeaway

The evidence was evenly split: 2 studies reported statistically significant symptom improvements, while 2 did not find a significant difference. This does not establish a reliable overall benefit or prove that biofeedback has no effect. Different ages and disorder subtypes make the small evidence base difficult to interpret as one treatment result.

Keep in mind: This abstract-based account lacks comparator descriptions, symptom effect sizes and individual study durations. The review's suggestion that treatment duration matters does not establish a minimum effective course or justify a treatment prescription.

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Abstract-based explanation

Gut health2 min read

Bacterial powder as an added treatment showed favourable results in children with peritonitis

Children receiving lactic acid bacteria powder alongside routine treatment had a higher reported treatment-response rate than those receiving routine care alone. The abstract does not define that response or quantify the difference.

Randomized trial assigning children to routine care or routine care plus bacterial powder.2025
30-second takeaway

Among children with bacterial peritonitis, adding the bacterial powder to routine treatment produced a higher study-defined clinical effectiveness rate than routine treatment alone. Blood measurements and intestinal findings also favoured the added-treatment group. However, the abstract provides no response rates, effect sizes, or definition of clinical effectiveness, limiting how clearly readers can judge the benefit.

Keep in mind: Treatment duration, the bacterial preparation's details, statistical uncertainty, and the response definition are absent. The reported absence of drug-related adverse reactions during treatment does not establish safety beyond the observation period.

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Abstract-based explanation

Gut health2 min read

Prebiotic fibre did not clearly change bone-related blood markers in type 2 diabetes

Inulin-type fructans showed no statistically significant differences from a control supplement in the measured blood markers. That does not establish equivalent effects or unchanged bone strength.

Randomized, double-blind crossover trial: participants received both supplements in separate periods.2025
30-second takeaway

For people with type 2 diabetes, inulin-type fructans produced no statistically significant differences from maltodextrin in blood calcium, magnesium, vitamin D, or bone turnover markers. Exploratory correlations involving gut microbes raised further research questions. They do not overturn the treatment finding or establish that the supplement changes bone strength or fracture risk.

Keep in mind: The trial included a small group and short treatment periods. The reported outcomes were blood measurements. Statistically nonsignificant differences leave uncertainty and do not demonstrate equivalence between supplements.

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Abstract-based explanation

Gut health2 min read

Intestinal worm infection was linked to greater gut bacterial diversity

A synthesis of human studies linked helminth infection with more diverse and richer gut bacterial communities. The abstract does not show whether those differences translate into better health.

Systematic review and meta-analysis of 19 human research articles.2023
30-second takeaway

People with intestinal worm infections had greater bacterial diversity and richness in the pooled human evidence. Those outcomes describe the makeup of gut microbial communities, not a demonstrated health benefit. The review does not establish that infection improves disease outcomes or vaccine responses, or that the infections caused the observed microbial differences.

Keep in mind: The abstract provides no numerical effect sizes, confidence intervals, participant count, or follow-up periods. This limits an abstract-based assessment of the size, precision, and persistence of the reported differences.

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Abstract-based explanation

Gut health2 min read

Gut microbial diversity varied across living settings in Sub-Saharan Africa

A systematic review found differences in overall microbial diversity, while patterns for specific bacterial groups were inconsistent. Diet and intestinal parasites were also linked with microbial composition.

Systematic review of 23 studies.2023
30-second takeaway

The review found differences in overall gut microbial diversity across settings, with hunter-gatherers showing higher diversity than rural and urban residents in its results section. It did not find a consistent pattern in the relative abundance of individual bacterial groups. These associations do not establish that urbanization itself changes the microbiome or causes illness.

Keep in mind: This abstract-based summary cannot resolve the inconsistent bacterial-group results: the authors cite limited statistical power and varied methods and designs as possible explanations. Follow-up durations and quantitative pooled estimates are not reported.

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Abstract-based explanation

Gut healthPaper record

Dietary Polyphenols as Modulators of Bifidobacterium in the Human Gut Microbiota.

Meta-analysis · Nutrients · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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Gut healthPaper record

Effects of Polyphenols on Gut Health and Inflammation in Overweight and Obese Populations: A Systematic Review and Meta-analysis of Dose, Duration, and Food Matrix.

Meta-analysis (title) · Nutr Rev · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis (title)2026
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Gut healthPaper record

Research progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review.

Review · Front Pharmacol · 2026. Source record refreshed; an explanation has not been reviewed.

Review2026
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Gut healthPaper record

Association between the Gut Microbiota and Depression in Asian Populations: A Systematic Review and Meta-Analysis.

Systematic review · Dig Dis · 2026. Source record refreshed; an explanation has not been reviewed.

Systematic review2026
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Gut healthPaper record

Psychobiotics for the treatment of neuropsychiatric, neurodegenerative, and neurodevelopmental disorders: A systematic review.

Systematic review · Prog Neuropsychopharmacol Biol Psychiatry · 2026. Source record refreshed; an explanation has not been reviewed.

Systematic review2026
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Gut healthPaper record

Butyrate-Producing Bacteria as a Keystone Species of the Gut Microbiome: A Systemic Review of Dietary Impact on Gut-Brain and Host Health.

Systematic review · Int J Mol Sci · 2026. Source record refreshed; an explanation has not been reviewed.

Systematic review2026
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Gut healthPaper record

Probiotic Supplementation and Bone Health Parameters in Adults: A Systematic Review and Meta-Analysis.

Meta-analysis · Osteoporos Int · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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Gut healthPaper record

The Effect of Chewing Gum on Postoperative Gastrointestinal Function Recovery: A Systematic Review and Meta-analysis.

Meta-analysis · Ann Surg Oncol · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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Gut healthPaper record

Microbiome dynamics in attention-deficit hyperactivity disorder: A systematic review and meta-analysis decoding the role of gut dysbiosis and potential dietary interventions.

Meta-analysis · Eur Child Adolesc Psychiatry · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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Gut healthPaper record

A Systematic Review on Effect of Bifidobacterium Isolated from Skin Microbiota on GLP-1 Production to Alleviate Human Ailments.

Systematic review · Probiotics Antimicrob Proteins · 2026. Source record refreshed; an explanation has not been reviewed.

Systematic review2026
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Gut healthPaper record

Effect of consumption of Brazilian berries on intestinal health: a systematic review of in vivo studies.

Systematic review · Crit Rev Food Sci Nutr · 2026. Source record refreshed; an explanation has not been reviewed.

Systematic review2026
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Gut healthPaper record

From Gut to Skeletal Muscle: Synergistic Effects of Probiotics and Spirulina Supplementation on Soccer Players' Performance and Body Composition.

Randomized controlled trial · Probiotics Antimicrob Proteins · 2026. Source record refreshed; an explanation has not been reviewed.

Randomized controlled trial2026
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Gut healthPaper record

Meta-analyses of the global impact of non-antibiotic feed additives on livestock performance and health.

Meta-analysis · J Adv Res · 2026. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2026
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Gut healthPaper record

The efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials.

Meta-analysis · BMC Psychiatry · 2025. Source record refreshed; an explanation has not been reviewed.

Meta-analysis2025
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Gut healthPaper record

Application of novel nosocomial infection prevention and control combined with intestinal probiotics in children with hand, foot and mouth disease.

Randomized controlled trial · J Pak Med Assoc · 2025. Source record refreshed; an explanation has not been reviewed.

Randomized controlled trial2025
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Gut healthPaper record

The gut microbiota of Indigenous populations in the context of dietary westernization: a systematic review and meta-analysis.

Systematic review · Front Nutr · 2025. Source record refreshed; an explanation has not been reviewed.

Systematic review2025
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Gut healthPaper record

Exercise-induced modulation of gut microbiota in individuals with obesity and type 2 diabetes: a systematic review and meta-analysis.

Systematic review · Front Microbiol · 2025. Source record refreshed; an explanation has not been reviewed.

Systematic review2025
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Gut healthPaper record

Nonpharmacologic treatment for elderly with constipation: a systematic review and meta-analysis.

Systematic review · Front Med (Lausanne) · 2025. Source record refreshed; an explanation has not been reviewed.

Systematic review2025
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