Endometriosis group had smaller blood-pressure rises during laboratory tests
Women with endometriosis had smaller blood-pressure increases during cold exposure and handgrip testing than healthy controls. The aspirin comparison detected no effect on these responses.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
In a small laboratory study, women with endometriosis showed smaller blood-pressure rises than healthy controls during cold exposure and handgrip testing, contrary to the researchers’ prediction. The aspirin-versus-placebo comparison detected no effect on these responses. These results describe brief physiological reactions and do not establish higher or lower cardiovascular risk, or aspirin’s effects on long-term health.
The groups were small, and outcomes were laboratory pressure responses rather than cardiovascular events. Endometriosis status was not randomized, so the group differences cannot establish that endometriosis caused the altered responses.
What researchers found
Mean arterial pressure, an average blood-pressure measure
During the 3-minute cold-water challenge, pressure rose by 21±16 mm Hg in the endometriosis group versus 34±20 mm Hg in healthy controls (P<0.01).
The prediction was reversed
Researchers expected the endometriosis group’s pressure to rise more during the challenges. The observed pattern went in the opposite direction. The measurement was a response to testing, rather than an assessment of cardiovascular events.
A separate drug comparison
The crossover design compared aspirin with placebo within participants. The reported null result concerns pressure responses during these tests; it cannot establish that aspirin has no effect on other outcomes.
The original publication
Altered Blood Pressure Reflexes in Women With Endometriosis.
Williams AC, Alexander LM
Hypertension · 2025
- PubMed ID
- 40747556
- Record checked
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