When the failing heart's workload and energy supply fall out of step
A review describes different ways that heart failure can disrupt the match between pumping work and cellular energy production. It discusses mechanisms and potential treatment targets, rather than testing a therapy.
Based on the published abstract. The full paper may contain additional methods, results and limitations.
The 30-second takeaway
The review's central idea is that heart muscle can struggle when its mechanical work and energy supply no longer match. It describes different routes to that mismatch in heart failure with reduced or preserved pumping fraction. These are explanations of disease biology; the abstract supplies no patient-level comparison of treatment benefits.
The abstract does not describe study selection, evidence-quality assessment or participant characteristics. It offers a mechanistic account without quantified clinical outcomes or comparative treatment effects.
Different routes to an energy mismatch
With reduced pumping fraction, the review emphasizes problems linking electrical activation to muscle contraction. With preserved pumping fraction, increased workload is described as exceeding energy supplied by mitochondria, the cells' energy-producing structures.
Another proposed contributor
Both pathways involve oxidative stress, an imbalance in protection against damaging chemical reactions. The review connects this with harmful changes in heart structure and function, while discussing possible treatment targets rather than reporting their clinical effectiveness.
The original publication
Mechano-energetic uncoupling in heart failure.
Aksentijevic D, Sedej S, Fauconnier J et al.
Nat Rev Cardiol · 2025
- PubMed ID
- 40544170
- Record checked
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